Despite their similar physicochemical properties, recent studies have demonstrated that lanthanides can display different biological behaviors. Hence, the lanthanide series can be divided into three parts, namely early, mid, and late lanthanides, based on their interactions with biological systems. In particular, the late lanthanides demonstrate distinct, but poorly understood biological activity. In the current study, we employed genome-wide functional screening to help understand biological effects of exposure to Yb(III) and Lu(III), which were selected as representatives of the late lanthanides. As a model organism, we used Saccharomyces cerevisiae, since it shares many biological functions with humans. Analysis of the functional screening results indicated toxicity of late lanthanides is consistent with disruption of vesicle-mediated transport, and further supported a role for calcium transport processes and mitophagy in mitigating toxicity. Unexpectedly, our analysis suggested that late lanthanides target proteins with SH3 domains, which may underlie the observed toxicity. This study provides fundamental insights into the unique biological chemistry of late lanthanides, which may help devise new avenues toward the development of decorporation strategies and bio-inspired separation processes.

中文翻译：

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通过全基因组相互作用筛选晚期镧系元素的复杂生物学行为。

尽管它们具有相似的物理化学性质，但最近的研究表明，镧系元素可以表现出不同的生物学行为。因此，根据与生物系统的相互作用，镧系元素可以分为三个部分，即早期、中期和晚期稀土元素。特别是，晚期镧系元素表现出独特但人们知之甚少的生物活性。在当前的研究中，我们采用全基因组功能筛选来帮助了解暴露于 Yb(III) 和 Lu(III) 的生物效应，它们被选为晚期镧系元素的代表。作为模式生物，我们使用酿酒酵母，因为它与人类具有许多相同的生物学功能。功能筛选结果的分析表明，晚镧系元素的毒性与囊泡介导的转运的破坏一致，并进一步支持钙转运过程和线粒体自噬在减轻毒性中的作用。出乎意料的是，我们的分析表明晚期镧系元素靶向具有 SH3 结构域的蛋白质，这可能是观察到的毒性的基础。这项研究提供了对晚期镧系元素独特生物化学的基本见解，这可能有助于设计开发装饰策略和仿生分离过程的新途径。