Recent rapid development of cancer therapy has come about with the paradigm shift from the traditional goal of targeting cancer cells themselves, to reprograming the immune tumor microenvironment. Accumulating evidence shows that compounds that target epigenetic regulation, called epidrugs, play a crucial role in mediating the immunogenicity of cancer cells and in reshaping antitumor immunity. A large body of literature has recognized natural compounds as epigenetic modulators for their immunomodulatory effects and anticancer potential. Unifying our understanding of the role of these biologically active compounds in immuno-oncology may open new avenues for more effective cancer therapies. In this review, we explore how natural compounds modulate the epigenetic machinery to shape antitumor immune response, highlighting the promise offered by the Mother Nature that could be exploited therapeutically to improve outcomes for cancer patients.

中文翻译：

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大自然所提供的：免疫肿瘤学的机会。

近年来癌症治疗的快速发展已经实现了从靶向癌细胞本身的传统目标到重新编程免疫肿瘤微环境的范式转变。越来越多的证据表明，针对表观遗传调控的化合物（称为表药物）在介导癌细胞的免疫原性和重塑抗肿瘤免疫方面发挥着至关重要的作用。大量文献已将天然化合物视为表观遗传调节剂，因为它们具有免疫调节作用和抗癌潜力。统一我们对这些生物活性化合物在免疫肿瘤学中的作用的理解可能会为更有效的癌症治疗开辟新途径。在这篇综述中，我们探讨了天然化合物如何调节表观遗传机制以塑造抗肿瘤免疫反应，