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Chondroitin Sulfate Alleviated Obesity by Modulating Gut Microbiota and Liver Metabolome in High-Fat-Diet-Induced Obese Mice
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-06-09 , DOI: 10.1021/acs.jafc.3c02642 Ruichang Gao 1 , Zexiu Qi 1 , Jie Lin 1 , Ge Wang 1 , Ge Chen 1 , Li Yuan 1 , Quancai Sun 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-06-09 , DOI: 10.1021/acs.jafc.3c02642 Ruichang Gao 1 , Zexiu Qi 1 , Jie Lin 1 , Ge Wang 1 , Ge Chen 1 , Li Yuan 1 , Quancai Sun 1
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Chondroitin sulfate (CS) is a special bioactive substance with lipid metabolism regulation functions; its molecular mechanisms, however, need further study. This study aimed to study the role of gut microbiota and liver metabolome in the anti-obesity effects of CS. The results demonstrated that CS significantly reduced body weight gain and alleviated insulin resistance and dyslipidemia induced by high-fat diet treatment. Moreover, CS interestingly increased the content of Firmicutes in intestinal microbiota. Further studies showed that there were 11 different metabolites involved in metabolic pathways, including the unsaturated fatty acid biosynthesis pathway, primary bile acid biosynthesis, and taurine and hypotaurine metabolism. In addition, Spearman’s correlation analysis indicated that the anti-obesity effect of CS is closely related to liver metabolic regulation. Overall, these results provide a possible molecular mechanism by which CS reduces body weight and lipid accumulation.
中文翻译：
硫酸软骨素通过调节高脂肪饮食诱导的肥胖小鼠的肠道微生物群和肝脏代谢组来减轻肥胖
硫酸软骨素（CS）是一种具有脂质代谢调节功能的特殊生物活性物质；但其分子机制尚需进一步研究。本研究旨在研究肠道微生物群和肝脏代谢组在 CS 的抗肥胖作用中的作用。结果表明，CS显着降低体重增加，减轻高脂饮食治疗引起的胰岛素抵抗和血脂异常。此外，有趣的是，CS 还增加了肠道微生物群中厚壁菌门的含量。进一步的研究表明，有11种不同的代谢物参与代谢途径，包括不饱和脂肪酸生物合成途径、初级胆汁酸生物合成以及牛磺酸和亚牛磺酸代谢。此外，Spearman相关分析表明CS的抗肥胖作用与肝脏代谢调节密切相关。总的来说，这些结果提供了 CS 减轻体重和脂质积累的可能分子机制。
更新日期：2023-06-09
中文翻译：
硫酸软骨素通过调节高脂肪饮食诱导的肥胖小鼠的肠道微生物群和肝脏代谢组来减轻肥胖
硫酸软骨素（CS）是一种具有脂质代谢调节功能的特殊生物活性物质；但其分子机制尚需进一步研究。本研究旨在研究肠道微生物群和肝脏代谢组在 CS 的抗肥胖作用中的作用。结果表明，CS显着降低体重增加，减轻高脂饮食治疗引起的胰岛素抵抗和血脂异常。此外，有趣的是，CS 还增加了肠道微生物群中厚壁菌门的含量。进一步的研究表明，有11种不同的代谢物参与代谢途径，包括不饱和脂肪酸生物合成途径、初级胆汁酸生物合成以及牛磺酸和亚牛磺酸代谢。此外，Spearman相关分析表明CS的抗肥胖作用与肝脏代谢调节密切相关。总的来说，这些结果提供了 CS 减轻体重和脂质积累的可能分子机制。
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