Corn Silk Flavonoids Ameliorate Hyperuricemia via PI3K/AKT/NF-κB Pathway,Journal of Agricultural and Food Chemistry

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Corn Silk Flavonoids Ameliorate Hyperuricemia via PI3K/AKT/NF-κB Pathway
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-06-09 , DOI: 10.1021/acs.jafc.3c03422
Xizhu Wang _{1,

2} , Liu Dong _{1,

2} , Yifei Dong _{1,

2} , Zhijie Bao _{1,

2} , Songyi Lin _{1,

2}

Affiliation

Hyperuricemia (HUA) is a widespread metabolic disease marked by an elevated level of uric acid, and is a risk factor for premature death. The protective effect of corn silk flavonoids (CSF) against HUA and its potential mechanisms were explored. Five important apoptosis and inflammation-related signaling pathways were identified by network pharmacological analysis. The CSF exhibited significant uric acid (UA)-lowering activity in vitro by decreasing xanthine oxidase (XOD) and increasing hypoxanthine–guanine phosphoribosyl transferase levels. In a potassium oxonate-induced HUA in vivo, CSF treatment effectively inhibited XOD activity and promoted UA excretion. Furthermore, it decreased the levels of TNF-α and IL-6 and restored pathological damage. In summary, CSF is a functional food component to improve HUA by reducing inflammation and apoptosis through the down-regulating PI3K/AKT/NF-κB pathway.

中文翻译：

玉米须黄酮通过 PI3K/AKT/NF-κB 通路改善高尿酸血症

高尿酸血症（HUA）是一种广泛存在的代谢性疾病，以尿酸水平升高为特征，是过早死亡的危险因素。探讨玉米须黄酮（CSF）对 HUA 的保护作用及其潜在机制。通过网络药理学分析确定了五个重要的细胞凋亡和炎症相关信号通路。CSF通过降低黄嘌呤氧化酶 (XOD) 和增加次黄嘌呤-鸟嘌呤磷酸核糖转移酶水平，在体外表现出显着的降尿酸 (UA) 活性。体内氧酸钾诱导的 HUA、CSF处理有效抑制XOD活性并促进UA排泄。此外，它还降低了 TNF-α 和 IL-6 的水平并恢复了病理损伤。综上所述，CSF是一种通过下调PI3K/AKT/NF-κB通路减少炎症和细胞凋亡来改善HUA的功能性食品成分。

更新日期：2023-06-09

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