Relationship of Gene-Structure–Antioxidant Ability of Exopolysaccharides Derived from Lactic Acid Bacteria: A Review,Journal of Agricultural and Food Chemistry

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Relationship of Gene-Structure–Antioxidant Ability of Exopolysaccharides Derived from Lactic Acid Bacteria: A Review
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-06-08 , DOI: 10.1021/acs.jafc.3c00532
Zifang Zhou _{1,

2} , Xiaoqun Zeng _{1,

2} , Zhen Wu _{1,

2} , Yuxing Guo _{1,

3} , Daodong Pan _{1,

2}

Affiliation

Polysaccharides derived from lactic acid bacteria (LAB) have widespread industrial applications owing to their excellent safety profile and numerous biological properties. The antioxidant activity of exopolysaccharides (EPS) offers defense against disease conditions caused by oxidative stress. Several genes and gene clusters are involved in the biosynthesis of EPS and the determination of their structures, which play an important role in modulating their antioxidant ability. Under conditions of oxidative stress, EPS are involved in the activation of the nonenzyme (Keap1-Nrf2-ARE) response pathway and enzyme antioxidant system. The antioxidant activity of EPS is further enhanced by the targeted alteration of their structures, as well as by chemical methods. Enzymatic modification is the most commonly used method, though physical and biomolecular methods are also frequently used. A detailed summary of the biosynthetic processes, antioxidant mechanisms, and modifications of LAB-derived EPS is presented in this paper, and their gene-structure–function relationship has also been explored.

中文翻译：

乳酸菌胞外多糖的基因结构与抗氧化能力的关系：综述

源自乳酸菌（LAB）的多糖因其优异的安全性和众多的生物学特性而具有广泛的工业应用。胞外多糖 (EPS) 的抗氧化活性可以防御氧化应激引起的疾病。一些基因和基因簇参与 EPS 的生物合成及其结构的确定，在调节其抗氧化能力方面发挥着重要作用。在氧化应激条件下，EPS参与非酶（Keap1-Nrf2-ARE）反应途径和酶抗氧化系统的激活。EPS 的抗氧化活性通过有针对性的结构改变以及化学方法得到进一步增强。酶法修饰是最常用的方法，尽管物理和生物分子方法也经常使用。本文详细总结了 LAB 衍生的 EPS 的生物合成过程、抗氧化机制和修饰，并探讨了它们的基因-结构-功能关系。

更新日期：2023-06-08

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