Vitamin B is widely applied in the healthcare and food industry as an antineuritic and antioxidant to maintain the normal functioning of nerve conduction, the heart, and the gastrointestinal tract. This study reports on an integrated eight-step continuous-flow synthesis of vitamin B from commercially available 2-cyanoacetamide. The proposed continuous-flow process is based on advances in chemistry, engineering, and equipment design, and affords improved performance and safety compared with batch-mode manufacturing. Several challenges were precisely investigated and controlled, including mixing, unexpected clogging, solvent switches, an exothermic reaction, and the prevention of side reactions, using various micro-channel flow reactors, mixers, separators, and continuous filters. Vitamin B was produced with a separated yield of 47.7% and high purity, with a total residence time of about 3.5 h. This eight-step continuous-flow protocol enables technology involving up to six of the key principles of green chemistry. Hence, the application of flow technology is of paramount importance for improving security, reducing waste, and, in particular, improving the efficiency of batch operations that require several days for manufacturing.

中文翻译：

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维生素 B1 的八步连续流全合成

维生素B作为抗神经药和抗氧化剂广泛应用于医疗保健和食品工业，以维持神经传导、心脏和胃肠道的正常功能。本研究报告了从市售 2-氰基乙酰胺中集成八步连续流动合成维生素 B 的方法。所提出的连续流工艺基于化学、工程和设备设计的进步，与批量模式制造相比，可提供更高的性能和安全性。使用各种微通道流动反应器、混合器、分离器和连续过滤器，精确研究和控制了几个挑战，包括混合、意外堵塞、溶剂切换、放热反应和副反应的预防。维生素B分离收率47.7%，纯度高，总停留时间约3.5 h。这种八步连续流协议使技术能够涉及多达六个绿色化学的关键原理。因此，流程技术的应用对于提高安全性、减少浪费，特别是提高需要数天制造时间的批量操作的效率至关重要。