The Metabolostasis Network and the Cellular Depository of Aggregation-Prone Metabolites,Angewandte Chemie International Edition

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The Metabolostasis Network and the Cellular Depository of Aggregation-Prone Metabolites
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-06-02 , DOI: 10.1002/anie.202217622
Shon A Levkovich ₁ , Ehud Gazit _{1,

2,

3} , Dana Laor Bar-Yosef ₁

Affiliation

Metabolites are essential building blocks required for cellular function. Yet, like proteins, they tend to form toxic aggregates. Here, we expand the resemblance between protein and metabolite self-assembly, discussing the metastability of the soluble state of the latter. We suggest that a quality-control network, termed “metabolostasis”, has evolved to regulate the storage and retrieval of aggregation-prone metabolites and prevent disease onset.

中文翻译：

代谢稳定网络和易聚集代谢物的细胞储存库

代谢物是细胞功能所需的重要组成部分。然而，像蛋白质一样，它们往往会形成有毒的聚集体。在这里，我们扩展了蛋白质和代谢物自组装之间的相似性，讨论了后者可溶态的亚稳定性。我们认为，一个被称为“代谢稳态”的质量控制网络已经发展到可以调节易于聚集的代谢物的储存和检索并预防疾病的发生。

更新日期：2023-06-02

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