Advances in biomaterial science have allowed for unprecedented insight into the ability of material cues to influence stem cell function. These material approaches better recapitulate the microenvironment, providing a more realistic ex vivo model of the cell niche. However, recent advances in our ability to measure and manipulate niche properties in vivo have led to novel mechanobiological studies in model organisms. Thus, in this review, we will discuss the importance of material cues within the cell niche, highlight the key mechanotransduction pathways involved, and conclude with recent evidence that material cues regulate tissue function in vivo.

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获得物理：材料力学是一种内在的细胞线索

生物材料科学的进步使人们能够前所未有地了解材料线索影响干细胞功能的能力。这些材料方法更好地概括了微环境，提供了更逼真的细胞生态位离体模型。然而，我们在体内测量和操纵生态位特性的能力的最新进展导致了对模型生物的新的机械生物学研究。因此，在这篇综述中，我们将讨论物质线索在细胞生态位内的重要性，强调所涉及的关键机械转导途径，并以物质线索调节体内组织功能的最新证据作为结论。