Tissue-specific transcriptome analyses in Drosophila provide novel insights into the mode of action of the insecticide spinosad and the function of its target, nAChRα6,Pest Management Science

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Tissue-specific transcriptome analyses in Drosophila provide novel insights into the mode of action of the insecticide spinosad and the function of its target, nAChRα6
Pest Management Science ( IF 3.8 ) Pub Date : 2023-05-29 , DOI: 10.1002/ps.7585
Felipe Martelli ₁ , Thomas A Ravenscroft ₂ , William Hutchison ₁ , Philip Batterham ₁

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The insecticides spinosad and imidacloprid are neurotoxins with distinct modes of action. Both target nicotinic acetylcholine receptors (nAChRs), albeit different subunits. Spinosad is an allosteric modulator, that upon binding initiates endocytosis of its target, nAChRα6. Imidacloprid binding triggers excessive neuronal ion influx. Despite these differences, low-dose effects converge downstream in the precipitation of oxidative stress and neurodegeneration.

中文翻译：

果蝇组织特异性转录组分析为杀虫剂多杀菌素的作用模式及其靶标 nAChRα6 的功能提供了新的见解

杀虫剂多杀菌素和吡虫啉是具有不同作用方式的神经毒素。尽管亚基不同，但两者都以烟碱乙酰胆碱受体 (nAChR) 为目标。多杀菌素是一种变构调节剂，结合后启动其靶标 nAChRα6 的内吞作用。吡虫啉结合引发过度的神经元离子流入。尽管存在这些差异，低剂量效应在氧化应激和神经变性的沉淀中汇聚到下游。

更新日期：2023-05-29

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