Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study,Child Development

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Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study
Child Development ( IF 3.9 ) Pub Date : 2023-05-02 , DOI: 10.1111/cdev.13938
Lauren C Shuffrey ₁ , Santiago Morales ₂ , Melanie H Jacobson ₃ , Michelle Bosquet Enlow _{4,

5} , Akhgar Ghassabian ₆ , Amy E Margolis ₁ , Maristella Lucchini ₁ , Kecia N Carroll ₇ , Rosa M Crum ₈ , Dana Dabelea ₉ , Arielle Deutsch ₁₀ , William P Fifer _{1,

11} , Brandon Goldson ₇ , Christine W Hockett _{10,

12} , W Alex Mason ₁₃ , Lisette T Jacobson ₁₄ , Thomas G O'Connor ₁₅ , Nicolò Pini ₁ , Yael Rayport ₁ , Ayesha Sania ₁ , Leonardo Trasande ₁₆ , Rosalind J Wright ₇ , Seonjoo Lee ₁₇ , Catherine Monk _{1,

18,

19} ,

Affiliation

Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Department of Psychology, University of Southern California, Los Angeles, California, USA.
Department of Pediatrics, Division of Environmental Pediatrics, New York University School of Medicine, New York, New York, USA.
Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, Massachusetts, USA.
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Department of Pediatrics, New York University School of Medicine, New York, New York, USA.
Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Avera Research Institute, Sioux Falls, South Dakota, USA.
Division of Developmental Neuroscience, New York State Psychiatric Institute, New York, New York, USA.
Department of Pediatrics, University of South Dakota School of Medicine, Sioux Falls, South Dakota, USA.
Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Department of Population Health, Department of Obstetrics & Gynecology, University of Kansas School of Medicine, Wichita, Kansas, USA.
Departments of Psychiatry, Psychology, Neuroscience, and Obstetrics and Gynecology, University of Rochester, Rochester, New York, USA.
Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.
Mailman School of Public Health, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Departments of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York, USA.
Division of Behavioral Medicine, New York State Psychiatric Institute, New York, New York, USA.

This study examined the association of gestational diabetes mellitus (GDM), prenatal, and postnatal maternal depressive symptoms with externalizing, internalizing, and autism spectrum problems on the Preschool Child Behavior Checklist in 2379 children aged 4.12 ± 0.60 (48% female; 47% White, 32% Black, 15% Mixed Race, 4% Asian, <2% American Indian/Alaskan Native, <2% Native Hawaiian; 23% Hispanic). Data were collected from the NIH Environmental influences on Child Health Outcomes (ECHO) Program from 2009-2021. GDM, prenatal, and postnatal maternal depressive symptoms were each associated with increased child externalizing and internalizing problems. GDM was associated with increased autism behaviors only among children exposed to perinatal maternal depressive symptoms above the median level. Stratified analyses revealed a relation between GDM and child outcomes in males only.

中文翻译：

妊娠糖尿病和围产期母亲抑郁与幼儿行为问题的关联：环境对儿童健康结果的影响 (ECHO) 研究

本研究对 2379 名 4.12 ± 0.60 岁的儿童（48% 为女性；47% 为白人）调查了妊娠期糖尿病 (GDM)、产前和产后母亲抑郁症状与学龄前儿童行为检查表中的外化、内化和自闭症谱系问题之间的关系。，32% 黑人，15% 混血，4% 亚洲人，<2% 美洲印第安人/阿拉斯加原住民，<2% 夏威夷原住民；23% 西班牙裔）。数据收集自 2009 年至 2021 年 NIH 环境对儿童健康结果的影响 (ECHO) 计划。 GDM、产前和产后母亲抑郁症状均与儿童外化和内化问题的增加有关。仅在围产期母亲抑郁症状高于中位水平的儿童中，GDM 与自闭症行为增加相关。分层分析仅揭示了男性 GDM 与儿童结局之间的关系。

更新日期：2023-05-02

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