Class I myosin (myosin-1) is a small, single-headed myosin, distributing from lower eukaryotes (such as fungi) to higher eukaryotes (such as vertebrates). Being able to interact with actin via the motor domain and to bind to membrane via the tail domain, myosin-1 plays a number of fundamental functions at the membrane–cytoskeleton interface. In fungi, myosin-1 is essential for many cellular processes, including endocytosis, hyphal growth, endoplasmic reticulum (ER) remodeling, and pathogenicity. In this review, we summarize the recent progress of fungal myosin-1 research in the past few years. We first introduce basic structure and function of each fungal myosin-1 domains, then compare the recently solved three-dimensional structure of fungal myosin-1 with that of vertebrate myosin-1, and finally focus on how fungal myosin-1 might participate in endocytosis and ER remodeling.

I 类肌球蛋白 (myosin-1) 是一种小型单头肌球蛋白，分布于低等真核生物（如真菌）至高等真核生物（如脊椎动物）。myosin-1 能够通过运动域与肌动蛋白相互作用并通过尾域与膜结合，在膜-细胞骨架界面发挥许多基本功能。在真菌中，肌球蛋白 1 对于许多细胞过程至关重要，包括内吞作用、菌丝生长、内质网 (ER) 重塑和致病性。在这篇综述中，我们总结了近几年真菌肌球蛋白-1的研究进展。我们首先介绍了每个真菌 myosin-1 结构域的基本结构和功能，然后将最近解决的真菌 myosin-1 的三维结构与脊椎动物 myosin-1 的三维结构进行了比较，最后关注真菌 myosin-1 如何参与内吞作用和 ER 重塑。