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Nanoarchitectonics in combat against bacterial infection using molecular, interfacial, and material tools
Current Opinion in Colloid & Interface Science ( IF 8.9 ) Pub Date : 2023-04-28 , DOI: 10.1016/j.cocis.2023.101702
Jingwen Song , Kohsaku Kawakami , Katsuhiko Ariga

Nanoarchitectonics, as a post-nanotechnology concept, is the methodology for constructing functional materials from nano-units, which bridges the gap between nanotechnology and materials science. The research accomplishes advocating nanoarchitectonics has increased dramatically as overviewed in the initial part of this review. Then, as socially impactful subjects, we exemplify nanoarchitectonics research for bacterial infections according to classifications featured with molecular tools, interfaces, and hierarchically structured materials. In particular, this review article discusses namely three kinds of antibacterial strategies: (i) new antimicrobial agents and therapeutic modalities based on nanoarchitectonics present high bactericidal efficacy against methicillin-resistant Staphylococcus aureus; (ii) antimicrobial nanoarchitectonics structures are integrated into the surface of medical devices to detach or kill approaching bacteria; (iii) the nanoarchitectonics hydrogels act as antimicrobial reservoirs to produce sustained-release antimicrobial agents for long-lasting bacterial killing.



中文翻译:

使用分子、界面和材料工具对抗细菌感染的纳米建筑学

纳米建筑学作为后纳米技术的概念,是从纳米单元构建功能材料的方法论,弥合了纳米技术与材料科学之间的鸿沟。正如本综述开头部分概述的那样,研究成果对纳米建筑学的提倡急剧增加。然后,作为具有社会影响力的主题,我们根据分子工具、界面和分层结构材料的分类,举例说明细菌感染的纳米构造学研究。特别是,这篇评论文章讨论了三种抗菌策略:(i)基于纳米结构的新型抗菌剂和治疗方式对耐甲氧西林金黄色葡萄球菌具有很高的杀菌效果; (ii) 将抗菌纳米建筑结构集​​成到医疗设备的表面,以分离或杀死接近的细菌;(iii) nanoarchitectonics 水凝胶充当抗菌库,产生持续释放的抗菌剂,用于持久的细菌杀灭。

更新日期:2023-04-28
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