Abstract

DC Beads and CalliSpheres are commonly used microspheres in clinical transcatheter arterial chemoembolization, but these microspheres cannot be visualized by themselves. Therefore, in our previous study, we developed multimodal imaging nano-assembled microspheres (NAMs), which are visualized under CT/MR and the location of embolic microspheres can be determined during postoperative review, facilitating the evaluation of embolic areas and guiding subsequent treatment. Moreover, the NAMs can be carried with positively and negatively charged drugs, increasing the choice of drugs. Systematic comparative analysis of the pharmacokinetics of NAMs with commercially available DC Bead and CalliSpheres microspheres is important for evaluating the clinical application of NAMs. In our study, we compared the similarities and differences between NAMs and two drug-eluting beads (DEBs) in respect to drug loading capacity, drug release profiles, diameter variation and morphological characteristics. The results indicate that NAMs had good drug delivery and release characteristics as well as DC Bead and CalliSpheres in vitro experimental stage. Therefore, NAMs have a good application prospect in transcatheter arterial chemoembolization treatment of hepatocellular carcinoma.

摘要

DC Beads 和 CalliSpheres 是临床经导管动脉化疗栓塞术中常用的微球，但这些微球本身无法显影。因此，在我们之前的研究中，我们开发了多模态成像纳米组装微球（NAMs），其在 CT/MR 下可视化，并且可以在术后复查期间确定栓塞微球的位置，便于评估栓塞区域并指导后续治疗。此外，NAMs可以携带带正电荷和带负电荷的药物，增加了药物的选择范围。对 NAM 与市售 DC Bead 和 CalliSpheres 微球的药代动力学进行系统比较分析，对于评估 NAM 的临床应用非常重要。在我们的研究中，我们比较了 NAM 和两种药物洗脱珠 (DEB) 在载药量、药物释放曲线、直径变化和形态特征方面的异同。结果表明，NAMs 与 DC Bead 和 CalliSpheres 在体外实验阶段一样具有良好的药物递送和释放特性。因此，NAMs在肝细胞癌肝动脉化疗栓塞治疗中具有良好的应用前景。