ABSTRACT

Meerwein-Ponndorf-Verley (MPV) reduction is a highly selective, heterogeneously catalyzed process for the synthesis of alcohols from aldehydes and ketones under relatively mild reaction conditions. The reduction of the carbonyl group involves the transfer of a hydrogen atom from the alcohol, which, acts as a sacrificial reducing agent. Thanks to its simplicity and high variability and applicability, MPV has remained relevant over time. Recently, MPV has even become a cornerstone of basic organic chemistry, playing a key role in several cascade reactions in biomass transformation. Yet, despite extensive research on MPV, important questions are still unanswered, such as the specific role of acid and basic sites in the overall catalytic process. Here, we review advances on MPV made in the last 15 years, focusing on the catalytic materials and their properties and addressing topics ranging from classical metal oxide catalysis to new catalytic systems tested in MPV, including the synthesis of valuable products. This review is divided into four sections, namely the (1) introduction, summarizing the typical features of MPV, (2) classical studies on MPV, highlighting carbonyl group reduction as the conventional approach to synthesizing alcohols, and (3) MPV in biomass transformation, examining new applications of MPV in cascade reactions for biomass conversion into molecular platforms, followed by (4) conclusions and future perspectives on MPV heterogeneous catalysis reduction. Overall, the state of the art on MPV underscores the utility, potential and importance of this reaction not only for classical carbonyl reduction but also for biomass transformation over a wide range of catalytic materials and with various substrates.

摘要

Meerwein-Ponndorf-Verley (MPV) 还原是一种高度选择性的多相催化过程，用于在相对温和的反应条件下从醛和酮合成醇。羰基的还原涉及从醇中转移氢原子，醇充当牺牲还原剂。由于其简单性和高度可变性和适用性，MPV 随着时间的推移仍然具有重要意义。最近，MPV 甚至成为基础有机化学的基石，在生物质转化的多个级联反应中发挥关键作用。然而，尽管对 MPV 进行了广泛的研究，但重要的问题仍未得到解答，例如酸碱位点在整个催化过程中的具体作用。在这里，我们回顾了过去 15 年在 MPV 方面取得的进展，重点关注催化材料及其特性，并讨论从经典金属氧化物催化到在 MPV 中测试的新催化系统的主题，包括有价值产品的合成。本综述分为四个部分，即 (1) 介绍，总结 MPV 的典型特征，(2) MPV 的经典研究，强调羰基还原作为合成醇的常规方法，以及 (3) MPV 在生物质转化中的应用, 检查 MPV 在生物质转化为分子平台的级联反应中的新应用，然后是 (4) MPV 多相催化还原的结论和未来展望。总的来说，最先进的 MPV 强调了实用性，