Recent developments in ion mobility (IM) technology have expanded the capability to separate and characterize gas-phase ions of biomolecules, especially when paired with mass spectrometry. This next generation of IM technology has been ushered in by creative innovation focused on both instrument architectures and how electric fields are applied. In this review, we focus on the application of high-resolution and multidimensional IM to biomolecular analyses, encompassing the fields of glycomics, lipidomics, peptidomics, and proteomics. We highlight selected research that demonstrates the application of the new IM toolkit to challenging biomolecular systems. Through our review of recently published literature, we outline the current strengths of respective technologies and perspectives for future applications.

中文翻译：

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通过下一代离子淌度实验增强分析深度

离子淌度 (IM) 技术的最新发展扩大了分离和表征生物分子气相离子的能力，特别是与质谱法配合使用时。专注于仪器架构和电场应用方式的创造性创新引领了下一代 IM 技术。在这篇综述中，我们重点关注高分辨率和多维 IM 在生物分子分析中的应用，涵盖糖组学、脂质组学、肽组学和蛋白质组学领域。我们重点介绍了一些研究，这些研究展示了新的 IM 工具包在具有挑战性的生物分子系统中的应用。通过对最近发表的文献的回顾，我们概述了各自技术的当前优势和未来应用的前景。