The confinement of substrates inside the cavity of self-assembled capsules makes it possible to effectively catalyze organic reactions in a way that is analogous to how enzymes work in biological systems. Due to steric constraints, solvent exclusion, intermediates stabilization, and conformational control of substrates, chemical reactions taking place in a confined space may exhibit unique processes. As a result, the fundamental rules of organic reactivity are frequently broken. The hexameric capsule C_R, an intriguing supramolecular assembly formed by six resorcinarene 1 macrocycles and eight water molecules, is the subject of this review. This assembly has proven to be effective at catalyzing several chemical reactions by controlling reactivity and selectivity in its confined space.

将底物限制在自组装胶囊的空腔内，可以有效地催化有机反应，类似于酶在生物系统中的工作方式。由于空间限制、溶剂排除、中间体稳定和底物的构象控制，在密闭空间内发生的化学反应可能表现出独特的过程。结果，有机反应的基本规则经常被打破。六聚胶囊C _R是一种有趣的超分子组装体，由六个间苯二酚1大环和八个水分子组成，是本综述的主题。该组件已被证明可通过控制反应活性和有限空间内的选择性。