Overactive bladder syndrome with and without urinary incontinence and related conditions, signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract dysfunction, underactive bladder, stress urinary incontinence, and nocturia are common in the general population and have a major impact on the quality of life of the affected patients and their partners. Based on the deliberations of the subcommittee on pharmacological treatments of the 7th International Consultation on Incontinence, we present a comprehensive review of established drug targets in the treatment of overactive bladder syndrome and the aforementioned related conditions and the approved drugs used in its treatment. Investigational drug targets and compounds are also reviewed. We conclude that, despite a range of available medical treatment options, a considerable medical need continues to exist. This is largely because the existing treatments are symptomatic and have limited efficacy and/or tolerability, which leads to poor long-term adherence.

中文翻译：

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尿失禁及相关疾病的当前和新兴药理学靶点和治疗

伴有或不伴有尿失禁的膀胱过度活动症以及相关病症、体征和障碍，如逼尿肌过度活跃、神经源性下尿路功能障碍、膀胱活动不足、压力性尿失禁和夜尿，在一般人群中很常见，对质量有重大影响受影响的患者及其伴侣的生活。根据第 7 届失禁国际咨询药物治疗小组委员会的审议，我们对治疗膀胱过度活动症和上述相关病症的既定药物靶点以及用于其治疗的批准药物进行了全面审查。还审查了研究药物靶点和化合物。我们的结论是，尽管有一系列可用的医疗选择，相当大的医疗需求仍然存在。这主要是因为现有的治疗是对症的，疗效和/或耐受性有限，导致长期依从性差。