Abstract

Human struggle against the deadly disease conditions is continued since ages. The contribution of science and technology in fighting against these diseases cannot be ignored exclusively due to the invention of novel procedure and products, extending their size ranges from micro to nano. Recently nanotechnology has been gaining more consideration for its ability to diagnose and treat different cancers. Different nanoparticles have been used to evade the issues related with conservative anticancer delivery systems, including their nonspecificity, adverse effects and burst release. These nanocarriers including, solid lipid nanoparticles (SLNs), liposomes, nano lipid carriers (NLCs), nano micelles, nanocomposites, polymeric and magnetic nanocarriers, have brought revolutions in antitumor drug delivery. Nanocarriers improved the therapeutic efficacy of anticancer drugs with better accumulation at the specific site with sustained release, improved bioavailability and apoptosis of the cancer cells while bypassing the normal cells. In this review, the cancer targeting techniques and surface modification on nanoparticles are discussed briefly with possible challenges and opportunities. It can be concluded that understanding the role of nanomedicine in tumor treatment is significant, and therefore, the modern progressions in this arena is essential to be considered for a prosperous today and an affluent future of tumor patients.

摘要

人类与致命疾病的斗争自古以来一直在继续。由于新程序和产品的发明，将它们的尺寸范围从微米扩展到纳米，科学技术在对抗这些疾病方面的贡献不容忽视。最近，纳米技术因其诊断和治疗不同癌症的能力而受到更多关注。不同的纳米颗粒已被用于规避与保守的抗癌递送系统相关的问题，包括它们的非特异性、副作用和爆发释放。这些纳米载体包括固体脂质纳米颗粒 (SLN)、脂质体、纳米脂质载体 (NLC)、纳米胶束、纳米复合材料、聚合物和磁性纳米载体，为抗肿瘤药物递送带来了革命。纳米载体提高了抗癌药物的治疗效果，在特定部位更好地积累并持续释放，提高了癌细胞的生物利用度和凋亡，同时绕过正常细胞。在这篇综述中，简要讨论了癌症靶向技术和纳米粒子表面改性以及可能面临的挑战和机遇。可以得出结论，了解纳米医学在肿瘤治疗中的作用非常重要，因此，为了肿瘤患者今天的繁荣和富裕的未来，必须考虑这一领域的现代进展。简要讨论了癌症靶向技术和纳米粒子表面改性以及可能面临的挑战和机遇。可以得出结论，了解纳米医学在肿瘤治疗中的作用非常重要，因此，为了肿瘤患者今天的繁荣和富裕的未来，必须考虑这一领域的现代进展。简要讨论了癌症靶向技术和纳米粒子表面改性以及可能面临的挑战和机遇。可以得出结论，了解纳米医学在肿瘤治疗中的作用非常重要，因此，为了肿瘤患者今天的繁荣和富裕的未来，必须考虑这一领域的现代进展。