The plant hormone auxin is certainly the most studied developmental regulator in plants. The many functions of auxin during development, from the embryo to the root and shoot construction, are mediated by an ever-growing collection of molecular regulators, with an overwhelming degree of both ubiquity and complexity that we are still far from fully understanding and that biological experiments alone cannot grasp. In this review, we discuss how bioinformatics and computational modeling approaches have helped in recent years to explore this complexity and to push the frontiers of our understanding of auxin biology. We focus on how analysis of massive amounts of genomic data and construction of computational models to simulate auxin-regulated processes at different scales have complemented wet experiments to increase the understanding of how auxin acts in the nucleus to regulate transcription and how auxin movement between cells regulates development at the tissular scale.

中文翻译：

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解码生长素矩阵：通过计算机的眼睛了解生长素生物学

植物激素生长素无疑是植物中研究最多的发育调节剂。生长素在发育过程中的许多功能，从胚胎到根和芽的构建，都是由不断增长的分子调节因子集合介导的，其普遍性和复杂性具有压倒性的程度，我们仍然远未完全理解，并且生物仅靠实验是无法掌握的。在这篇综述中，我们讨论了近年来生物信息学和计算建模方法如何帮助探索这种复杂性并推动我们对生长素生物学理解的前沿。我们专注于分析大量基因组数据和构建计算模型来模拟不同规模的生长素调节过程如何补充湿实验，以增加对生长素如何在细胞核中调节转录以及细胞之间的生长素运动如何调节的理解组织尺度的发育。