As a result of an aging population, musculoskeletal disease is a growing source of health and economic burden in the United States. In 2019, musculoskeletal conditions affected approximately 127.4 million people (more than a third of the U.S. population); they were the top driver of health-care spending in 2016, with an estimated direct annual cost of $380.9 billion. While musculoskeletal conditions represent a substantial and growing burden in terms of prevalence, disability, and health-care costs, National Institutes of Health (NIH) research funding has remained disproportionately allocated to other disease conditions. Therefore, our purpose was to provide an assessment of the current burden of musculoskeletal disease in terms of prevalence, disability, and health-care costs, and compare the changing burden of disease to trends in NIH funding.

由于人口老龄化，肌肉骨骼疾病在美国日益成为健康和经济负担的来源。2019 年，肌肉骨骼疾病影响了大约 1.274 亿人（超过美国人口的三分之一）；他们是 2016 年医疗保健支出的最大推动力，估计每年的直接费用为 3809 亿美元。虽然肌肉骨骼疾病在患病率、残疾和医疗保健成本方面代表着巨大且不断增长的负担，但美国国立卫生研究院 (NIH) 的研究资金仍然不成比例地分配给其他疾病。因此，我们的目的是从患病率、残疾和医疗保健成本方面评估当前肌肉骨骼疾病的负担，并将不断变化的疾病负担与 NIH 资助趋势进行比较。