Plants’ ability to chemically modify core structures of specialized metabolites is the main reason why the plant kingdom contains such a wide and rich array of diverse compounds. One of the most important types of chemical modifications of small molecules is the addition of an acyl moiety to produce esters and amides. Large-scale phylogenomics analyses have shown that the enzymes that perform acyl transfer reactions on the myriad small molecules synthesized by plants belong to only a few gene families. This review is focused on describing the biochemistry, evolutionary origins, and chemical ecology implications of one of these families—the BAHD acyltransferases. The growth of advanced metabolomic studies coupled with next-generation sequencing of diverse plant species has confirmed that the BAHD family plays critical roles in modifying nearly all known classes of specialized metabolites. The current and future outlook for research on BAHDs includes expanding their roles in synthetic biology and metabolic engineering.

中文翻译：

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BAHD公司：BAHD酰基转移酶基因家族在植物中不断扩大的作用

植物对特定代谢物的核心结构进行化学修饰的能力是植物界包含如此广泛和丰富的多样化化合物的主要原因。小分子化学修饰最重要的类型之一是添加酰基部分以产生酯和酰胺。大规模系统发育分析表明，对植物合成的无数小分子进行酰基转移反应的酶仅属于少数基因家族。这篇综述的重点是描述这些家族之一——BAHD 酰基转移酶的生物化学、进化起源和化学生态学意义。先进代谢组学研究的发展加上不同植物物种的下一代测序已经证实 BAHD 家族在改变几乎所有已知类别的专门代谢物中发挥着关键作用。 BAHD 研究的当前和未来前景包括扩大其在合成生物学和代谢工程中的作用。