Club cell secretory protein (CCSP), also known as secretoglobin 1A1 (gene name SCGB1A1), is one of the most abundant proteins in the lung, primarily produced by club cells of the distal airway epithelium. At baseline, CCSP is found in large concentrations in lung fluid specimens and can also be detected in the blood and urine. Obstructive lung diseases are generally associated with reduced CCSP levels, thought to be due to decreased CCSP production or club cell depletion. Conversely, several restrictive lung diseases have been found to have increased CCSP levels both in the lung and in the circulation, likely related to club cell dysregulation as well as increasedlung permeability. Recent studies demonstrate multiple mechanisms by which CCSP dampens acute and chronic lung inflammation. Given these anti-inflammatory effects, CCSP represents a novel potential therapeutic modality in lung disease.

中文翻译：

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肺病中的俱乐部细胞分泌蛋白：新兴概念和潜在治疗方法

俱乐部细胞分泌蛋白 (CCSP)，也称为分泌球蛋白 1A1（基因名称 SCGB1A1），是肺部最丰富的蛋白质之一，主要由远端气道上皮的俱乐部细胞产生。基线时，CCSP 在肺液样本中浓度较高，并且在血液和尿液中也可检测到。阻塞性肺病通常与 CCSP 水平降低有关，这被认为是由于 CCSP 产生减少或俱乐部细胞耗竭所致。相反，已发现几种限制性肺病会导致肺部和循环中的 CCSP 水平升高，这可能与俱乐部细胞失调以及肺通透性增加有关。最近的研究证明了 CCSP 抑制急性和慢性肺部炎症的多种机制。鉴于这些抗炎作用，CCSP 代表了肺部疾病的一种新的潜在治疗方式。