Wnt signaling comprises a group of complex signal transduction pathways that play critical roles in cell proliferation, differentiation, and apoptosis during development, as well as in stem cell maintenance and adult tissue homeostasis. Wnt pathways are classified into two major groups, canonical (β-catenin-dependent) or non-canonical (β-catenin-independent). Most previous studies in the eye have focused on canonical Wnt signaling, and the role of non-canonical signaling remains poorly understood. Additionally, the crosstalk between canonical and non-canonical Wnt signaling in the eye has hardly been explored. In this review, we present an overview of available data on ocular non-canonical Wnt signaling, including developmental and functional aspects in different eye compartments. We also discuss important changes of this signaling in various ocular conditions, such as keratoconus, aniridia-related keratopathy, diabetes, age-related macular degeneration, optic nerve damage, pathological angiogenesis, and abnormalities in the trabecular meshwork and conjunctival cells, and limbal stem cell deficiency.

Wnt 信号传导包含一组复杂的信号转导途径，在发育过程中的细胞增殖、分化和凋亡以及干细胞维持和成体组织稳态中发挥关键作用。Wnt 通路分为两大类：经典（β-连环蛋白依赖性）或非经典（β-连环蛋白独立）。之前大多数眼科研究都集中在经典 Wnt 信号传导上，而对非经典信号传导的作用仍然知之甚少。此外，眼睛中规范和非规范 Wnt 信号传导之间的串扰几乎没有被探索过。在这篇综述中，我们概述了眼部非典型 Wnt 信号传导的可用数据，包括不同眼区的发育和功能方面。