Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and through the brain transports not only those water-like fluids but also any solutes they carry, including nutrients, drugs, and metabolic wastes. Passing through brain tissue primarily during sleep, this circulation has implications for neurodegenerative disorders including Alzheimer's disease, for tissue damage during stroke and cardiac arrest, and for flow-related disorders such as hydrocephalus and syringomyelia. Recent experimental results reveal several features of this flow, but other aspects are not fully understood, including its driving mechanisms. We review the experimental evidence and theoretical modeling of cerebrospinal fluid flow, including the roles of advection and diffusion in transporting solutes. We discuss both local, detailed fluid-dynamic models of specific components of the system and global hydraulic models of the overall network of flow paths.

中文翻译：

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脑脊液流量

脑脊液和间质液在中枢神经系统周围以及通过大脑的循环不仅输送这些水状液体，还输送它们携带的任何溶质，包括营养物质、药物和代谢废物。这种循环主要在睡眠期间穿过脑组织，对包括阿尔茨海默氏病在内的神经退行性疾病、中风和心脏骤停期间的组织损伤以及脑积水和脊髓空洞症等血流相关疾病有影响。最近的实验结果揭示了这种流动的几个特征，但其他方面尚未完全了解，包括其驱动机制。我们回顾了脑脊液流动的实验证据和理论模型，包括平流和扩散在输送溶质中的作用。我们讨论系统特定组件的局部详细流体动力学模型和整个流路网络的全局水力模型。