Cancer is a highly fatal disease without effective early-stage diagnosis and proper treatment. Along with the oncoproteins and oncometabolites, several organelles from cancerous cells are also emerging as potential biomarkers. Mitochondria isolated from cancer cells are one such biomarker candidates. Cancerous mitochondria exhibit different profiles compared with normal ones in morphology, genomic, transcriptomic, proteomic and metabolic landscape. Here, the possibilities of exploring such characteristics as potential biomarkers through single-cell omics and Artificial Intelligence (AI) are discussed. Furthermore, the prospects of exploiting the biomarker-based diagnosis and its futuristic utilization through circulatory tumor cell technology are analyzed. A successful alliance of circulatory tumor cell isolation protocols and a single-cell omics platform can emerge as a next-generation diagnosis and personalized treatment procedure.

中文翻译：

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线粒体起源的生物标志物：一种未来的癌症诊断。

癌症是一种高度致命的疾病，没有有效的早期诊断和适当的治疗。除了癌蛋白和癌代谢物，来自癌细胞的几种细胞器也正在成为潜在的生物标志物。从癌细胞中分离出的线粒体就是这样一种候选生物标志物。与正常线粒体相比，癌性线粒体在形态、基因组、转录组、蛋白质组和代谢方面表现出不同的特征。在这里，讨论了通过单细胞组学和人工智能 (AI) 探索潜在生物标志物等特征的可能性。此外，分析了通过循环肿瘤细胞技术开发基于生物标志物的诊断及其未来应用的前景。