Abstract

The use of polymeric fiber scaffolds in the biomedical field has been studied extensively in recent years. Among the principal methods used for obtaining the scaffold fibers at the micrometer to nanometer scale are: electrospinning, blow-spinning, and centrifugal spinning, with different peculiarities applying to each methodology. The centrifuge spinning method stands out for its simplicity and high rate of fiber production, despite the fact that it is little used to obtain fibers for scaffolds. The objective of this bibliographical review is to present a brief history of the centrifugal spinning method and the flexibility and easiness of its implementation when compared to the others. Furthermore, this article presents the types of medical applications being studied, the properties used in the methods (showing the current range of applications), and the characteristics of the polymer fibers and membranes obtained, as well as the performance of scaffolds in cell culture and in vivo tests, based on published work. This all illustrates the high potential of the technique for use in the biomedical field.

摘要

近年来，聚合物纤维支架在生物医学领域的应用得到了广泛的研究。用于获得微米至纳米级支架纤维的主要方法包括：静电纺丝、吹气纺丝和离心纺丝，每种方法都有不同的特点。尽管离心纺丝法很少用于获得支架用纤维，但其以其简单性和高纤维生产率而著称。本文献综述的目的是介绍离心纺纱的简史与其他方法相比，其实施的灵活性和简便性。此外，本文还介绍了正在研究的医疗应用类型、方法中使用的特性（显示了当前的应用范围）、所获得的聚合物纤维和膜的特性，以及支架在细胞培养和细胞培养中的性能。体内测试，基于已发表的工作。这一切都说明了该技术在生物医学领域的巨大潜力。