Recently, laser-induced nucleation (LIN) has been attracting significant attention because of its many advantages, including non-mechanical contact, spatiotemporal controllability, and high nucleation probability. Consequently, there is a high demand for precise control methods for polymorphism, particularly in the pharmaceutical industry. The precise control of nucleation and polymorphism, as well as the expansion of their versatility, is indispensable in elucidating the mechanism of nucleation and polymorphism. If LIN can be exploited to precisely control polymorphism, it will be possible to appropriately control the solubility, bioavailability, and stability of targets. Currently, numerous mechanisms for LIN involving targets, solvents, laser light sources, and additives have been proposed. In this review, the authors summarize the history and current state of the research on nucleation and LIN-controlled polymorphism reported over the past two decades while focusing on the different light sources (pulsed laser vs. continuous-wave laser). Furthermore, the authors introduce the classical nucleation and two-step nucleation models and discuss the similarities and differences in the mechanisms of nucleation and polymorphism control based on these two models.

近年来，激光诱导成核（LIN）具有非机械接触、时空可控性和成核概率高等诸多优点，引起了人们的广泛关注。因此，对多态性的精确控制方法有很高的需求，特别是在制药行业。成核和多晶型的精确控制，以及其通用性的扩展，对于阐明成核和多晶型的机制是必不可少的。如果可以利用LIN来精确控制多态性，就有可能适当控制靶标的溶解度、生物利用度和稳定性。目前，已经提出了许多涉及目标、溶剂、激光光源和添加剂的 LIN 机制。在本次审查中，与连续波激光）。此外，作者还介绍了经典形核和两步形核模型，并讨论了基于这两种模型的形核和多晶型控制机制的异同。