Schizotypy refers to a multidimensional construct that spans a range of cognitive, behavioral, and personality features, representing liability to psychosis on a continuum between health and illness. Schizotypy has been associated with functional and structural brain alterations as potential intermediate phenotypes on the developmental path to psychosis. We scanned the literature between February 2019 and August 1, 2020 using PubMed, Medline, APA PsycINFO, and ProQuest. We identified eligible articles conducted on participants assessed with psychometric schizotypy across the health-illness spectrum and reporting a direct statistic between schizotypy and a structural, task-related, or functional magnetic resonance imaging brain measure. Articles not peer-reviewed and not written in English were excluded. We systematically reviewed 84 studies that determined the changes in gray matter, brain activation, and connectivity associated with schizotypy in both healthy and clinical cohorts. Morphological and functional changes in the default and the frontoparietal networks, specifically frontal and temporal cortices, were most frequently associated with schizotypy. Yet, we were unable to identify consistent patterns of morphological or functional brain aberration associated with schizotypy, due to methodological differences between studies in the conceptualization and measurement of schizotypy. Efforts toward greater methodological concordance in future neuroimaging research of schizotypy are needed to improve the identification of brain-based endophenotypes for schizophrenia. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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精神分裂症的结构和功能神经相关性：系统评价。

精神分裂症是指跨越一系列认知、行为和人格特征的多维结构，代表在健康和疾病之间的连续统一体上对精神病的责任。精神分裂症与功能性和结构性大脑改变有关，作为精神病发展路径上的潜在中间表型。我们使用 PubMed、Medline、APA PsycINFO 和 ProQuest 扫描了 2019 年 2 月至 2020 年 8 月 1 日期间的文献。我们确定了对在健康疾病谱中使用心理分裂型评估的参与者进行的符合条件的文章，并报告了分裂型与结构、任务相关或功能磁共振成像大脑测量之间的直接统计数据。未经过同行评审且不是用英语撰写的文章被排除在外。我们系统回顾了 84 项研究，这些研究确定了健康和临床队列中与精神分裂症相关的灰质、大脑激活和连通性的变化。默认和额顶叶网络的形态和功能变化，特别是额叶和颞叶皮质，最常与精神分裂症相关。然而，由于精神分裂症的概念化和测量研究之间的方法学差异，我们无法确定与精神分裂症相关的形态学或功能性脑畸变的一致模式。需要努力在未来的精神分裂症神经影像学研究中实现更大的方法学一致性，以改进对精神分裂症基于大脑的内表型的识别。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。