The emergence of new two-dimensional materials (2DMs), especially the monoelemental materials (Xenes), in various fields of technology for their uses has shown potential nature, additionally, to fundamental science, addressing the new discoveries. The 2DMs Xenes (e.g., Group-IIIA (Borophene (2D-B), Gallenene (2D-Ga), and Aluminene (2D-Al)) Group-IVA (Silicene (2D-Si), Germanene (2D-Ge), Stanene (2D-Sn), and Graphene (2D-G)), Group-VA (Phosphorous (2D-P), Arsenene (2D-As), Antimonene (2D-Sb), and Bismuthene (2D-Bi)), Group-VIA (Tellurene (2D-Te) and Selenene(2D-Se)) for synthetic exploration are chemically tractable materials as considered capable mediators for biomedical applications due to their outstanding chemical, physical, optical and electronic properties, as well as in more than a number of other new bio-uses. In this timely updated review, we explained in detail the categorization of 2D-Xenes derived from their bulkiness properties. We also summarized the modification in synthetic methods of 2D-Xenes as well as their general properties. Moreover, for different biomedical uses the representative 2D-Xenes nanoplatforms are highlighted. At the end of this review, 2D-Xenes in the biomedicines research progress, perspectives, and challenges are discussed.

新的二维材料 (2DMs)，尤其是单元素材料 (Xenes) 的出现，在各种技术领域中的应用已经显示出潜在的性质，此外，对于基础科学，解决新发现。2DM X 烯（例如，IIIA 族（硼烯 (2D-B)、镓烯 (2D-Ga) 和铝烯 (2D-Al)） IVA 族（硅烯 (2D-Si)、锗烯 (2D-Ge)、 Stanene (2D-Sn), and Graphene (2D-G)), Group-VA (Phosphorous (2D-P), Arsenene (2D-As), Antimonene (2D-Sb), and Bismuthene (2D-Bi)),用于合成探索的 VIA 族（碲烯 (2D-Te) 和硒烯 (2D-Se)）是化学易处理的材料，由于其出色的化学、物理、光学和电子特性以及更多比许多其他新的生物用途。在这个及时更新的评论中，我们详细解释了 2D-Xene 的分类，这些分类源于它们的体积特性。我们还总结了 2D-Xenes 合成方法的改进及其一般性质。此外，对于不同的生物医学用途，突出显示了具有代表性的 2D-Xenes 纳米平台。在本综述的最后，讨论了生物医学研究进展、前景和挑战中的 2D-Xenes。