Annual Review of Biomedical Engineering ( IF 9.7 ) Pub Date : 2021-07-13 , DOI: 10.1146/annurev-bioeng-082020-035644 Lia A Stanciu 1, 2 , Qingshan Wei 3 , Amit K Barui 1, 2 , Noor Mohammad 3
Since aptamers were first reported in the early 2000s, research on their use for the detection of health-relevant analytical targets has exploded. This review article provides a brief overview of the most recent developments in the field of aptamer-based biosensors for global health applications. The review provides a description of general aptasensing principles and follows up with examples of recent reports of diagnostics-related applications. These applications include detection of proteins and small molecules, circulating cancer cells, whole-cell pathogens, extracellular vesicles, and tissue diagnostics. The review also discusses the main challenges that this growing technology faces in the quest of bringing these new devices from the laboratory to the market.
中文翻译：
用于全球健康应用的基于适体的生物传感器的最新进展
自 2000 年代初首次报道适配体以来，关于它们用于检测与健康相关的分析目标的研究呈爆炸式增长。这篇综述文章简要概述了基于适体的生物传感器在全球健康应用领域的最新发展。该评论提供了一般适配传感原理的描述，并跟进了最近诊断相关应用报告的示例。这些应用包括检测蛋白质和小分子、循环癌细胞、全细胞病原体、细胞外囊泡和组织诊断。该评论还讨论了这种不断发展的技术在将这些新设备从实验室推向市场的过程中面临的主要挑战。
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