RSC主编推荐：纳米领域精彩文章快览（免费阅读原文）

英国皇家化学会（RSC）是一个拥有超过175年历史的面向全球化学家的非营利会员制机构，旗下拥有43种期刊，其中很多在化学领域有很高影响力。为了进一步帮助广大读者追踪科技前沿热点，X-MOL团队与英国皇家化学会合作，推出英国皇家化学会期刊主编推荐的精彩文章快览，本期文章属“纳米领域”，英文点评来自英国皇家化学会期刊的主编。如果大家对我们的解读有更多的补充和点评，欢迎在文末写评论发表您的高见！

Chemical Science (IF: 8.668)

1. A bottom-up synthesis of rare-earth-hydrotalcite monolayer nanosheets toward multimode imaging and synergetic therapy

Chem. Sci., 2018, Advance Article

DOI: 10.1039/C8SC01288A

Scientists in Beijing developed a one-step “bottom-up” method to prepare rare-earth co-doped layered double hydroxide monolayer nanosheets, with controlled composition and uniform morphology. Gd³⁺ and Yb³⁺ were introduced into the host layer, resulting in the nanosheets exhibiting excellent magnetic resonance (MR)/X-ray computed tomography (CT) dual-mode imaging functionality. The nanosheets achieved a loading content of 925% of a chemotherapeutic drug SN38, much higher than previously reported drug carriers. This work has a promising application in cancer synergistic theranostics.

北京化工大学的研究人员发展了一种“自下而上”的方法来制备稀土共掺杂层状双氢氧化物单层纳米片，所得材料组成可控、形貌均匀。将Gd³⁺和Yb³⁺引入主体层，使得纳米片表现出了优秀的磁共振（MR）/X射线计算机断层成像（CT）双模式成像功能。该纳米片对化疗药物SN38的负载量达到了925%，远远高于此前报道的药物载体。这项工作在癌症协同诊疗领域有着广阔的应用前景。

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2. Versatile in situ synthesis of MnO₂ nanolayers on upconversion nanoparticles and their application in activatable fluorescence and MRI imaging

Chem. Sci., 2018, 9, 5427-5434

DOI: 10.1039/C8SC00490K

US and Chinese scientists developed a simple strategy for in situ growth of MnO₂ on the surfaces of oleic acid-capped hydrophobic upconversion nanoparticles (UNCPs). The group optimized the component concentrations in the Lemieux-von Rudloff reagent, shortening the oxidation time by a factor of two compared to the reported method. The presence of the surface MnO₂ precipitate allowed activatable MRI and fluorescence multimodal imaging after reduction to Mn²⁺ by intracellular GSH. This work could be used for applications such as luminescent labels and contrast agents.

湖南大学与佛罗里达大学的研究人员发展了一种简单策略，在油酸修饰的疏水性上转换纳米颗粒（UNCPs）表面上原位生长MnO₂。该研究小组优化了Lemieux-von Rudloff试剂中的组分浓度，与之前报道的方法相比氧化时间缩短了一半。颗粒表面沉积的MnO₂在被细胞内GSH还原成Mn²⁺之后，可激活MRI和荧光多模式成像。该成果可应用于发光标签和造影剂等。

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Nanoscale Horizons (IF: pending)

1. Single glucose molecule transport process revealed by force tracing and molecular dynamics simulations

Nanoscale Horiz., 2018, Advance Article

DOI: 10.1039/C8NH00056E

The authors use the atomic force microscopy (AFM)-based force-tracing technique to monitor the process of single-glucose transport, inspired by a "fishing" concept. They follow a single molecule transport process at a high temporal-spatial resolution. The forces to transport a single molecule of D-glucose across cell membranes and the corresponding transport interval were recorded. Combining with theoretical simulation, the transporting mechanism of glucose is further revealed at an atomic level, which was confirmed by the biological experiments. The approach leads to the first unambiguous description of the kinetics of the transport process in living cells at the single molecule level, which is significant for understanding how a membrane transporter works. This study provides a new concept of investigating the dynamic function of cell membranes.

中科院的研究人员受到“钓鱼”的启发，使用基于原子力显微镜（AFM）的力跟踪技术来监测单个葡萄糖的转运过程，实现了高时空分辨率下单分子转运过程的捕捉。研究记录了转运单个D-葡萄糖分子穿过细胞膜的力和相应的传输间隔。结合理论模拟，他们在原子水平上进一步揭示了葡萄糖的转运机制，这已被生物学实验证实。该方法首次明确描述了单分子水平上活细胞中转运过程的动力学，这对于理解膜转运蛋白的工作机制具有重要意义。本研究为细胞膜动态功能的研究提供了新概念。

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2. Multifunctional nanozymes: enzyme-like catalytic activity combined with magnetism and surface plasmon resonance

Nanoscale Horiz., 2018, Advance Article

DOI: 10.1039/C8NH00070K

A minireview discussing two representative types of multifunctional nanozymes, including iron oxide nanomaterials with magnetic properties and metal nanomaterials with surface plasmon resonance. The applications are also covered to show the great promise of such multifunctional nanozymes. Future challenges and prospects are discussed at the end of this review.

本篇综述讨论了两种代表性的多功能纳米酶，分别是具有磁性的氧化铁纳米材料和具有表面等离子体共振的金属纳米材料。本文介绍了这些多功能纳米酶的应用，展现了巨大的应用前景，并在文末讨论了未来的挑战和展望。

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3. Zinc oxide–black phosphorus composites for ultrasensitive nitrogen dioxide sensing

Nanoscale Horiz., 2018, Advance Article

DOI: 10.1039/C8NH00052B

Phosphorene, due to its ultrahigh surface–volume ratio, high chemical activity and excellent carrier mobility, has been shown to be promising for gas sensing. But current BP sensor suffers from some disadvantages: poor environmental stability, low sensitivity and long response–recovery process. Here, multi-layer black phosphorus (m-BP) is successfully incorporated in zinc oxide (ZnO) hollow spheres, thus forming hetero-structured ZnO–BP composites. Interestingly, the introduction of ZnO significantly enhances BP environmental stability, making it a suitable candidate to use in practice. Remarkably, ZnO–BP sensor exhibits higher response, outstanding selectivity, faster response and recovery dynamic process, and an ultralow detection limit of 1 ppb to NO₂ in contrast to graphene-, BP- and ZnO-based sensors, which were previously used. This study has provided a route in the search of BP-based materials with excellent properties for use in practice, in particular towards gas sensing.

由于其超高的表面-体积比、高化学活性和出色的载流子迁移率，磷烯在气体传感领域被证实为很有前景的材料。但是，目前的黑磷传感器仍存在一些缺点：环境稳定性差、灵敏度低、响应-恢复时间长。本研究将多层黑磷（m-BP）成功地结合到氧化锌（ZnO）空心球中，从而形成了异质结构的ZnO-BP复合材料。有趣的是，ZnO的引入显著增强了BP的环境稳定性，使其有望用于实际环境。值得注意的是，与以前报道的基于石墨烯、BP和ZnO的传感器相比，ZnO-BP传感器表现出了更高的响应、更优的选择性、更快的响应和恢复动态过程，对NO₂的检测限低至1 ppb。这项研究为寻找能够用于实际环境中，特别是用于气体传感，且具有卓越性能的基于BP的材料提供了一条新途径。

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