A new tetraphenylethylene based AIE sensor with light-up and tunable measuring range for adenosine triphosphate in aqueous solution and in living cells,Analyst

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A new tetraphenylethylene based AIE sensor with light-up and tunable measuring range for adenosine triphosphate in aqueous solution and in living cells
Analyst ( IF 3.6 ) Pub Date : 2017-10-26 00:00:00 , DOI: 10.1039/c7an01336a
Guoyu Jiang _{1,

2,

3,

4} , Wenping Zhu _{1,

2,

3,

4} , Qingqing Chen _{1,

2,

3,

4} , Aiping Shi _{1,

2,

3,

4} , Yongquan Wu _{1,

2,

3,

4} , Guanxin Zhang _{4,

5,

6,

7,

8} , Xun Li _{1,

2,

3,

4} , Yongdong Li _{1,

2,

3,

4} , Xiaolin Fan _{1,

2,

3,

4} , Jianguo Wang _{1,

2,

3,

4}

Affiliation

An AIE based tetraphenylethylene derivative (TPPTPE) was synthesized for light-up sensing of ATP in aqueous solution. The measuring range for ATP can be tuned by varying the concentration of the TPPTPE. A one-step straightforward quantitative analysis of the ATP level in cell lysates can be realized using the TPPTPE. Moreover, the TPPTPE can be used for monitoring apyrase activity in aqueous solution and detecting ATP both in living cancer cell lines and in living normal cell lines.

中文翻译：

一种新型的基于四苯乙烯的AIE传感器，具有亮点和可调的测量范围，用于检测水溶液和活细胞中的三磷酸腺苷

合成了一种基于AIE的四苯基乙烯衍生物（TPPTPE），用于水溶液中的ATP的光亮感测。可以通过改变TPPTPE的浓度来调整ATP的测量范围。使用TPPTPE可以实现对细胞裂解物中ATP水平的一步式直接定量分析。此外，TPPTPE可用于监测水溶液中的腺苷三磷酸双磷酸酶活性，并检测活癌细胞系和正常细胞系中的ATP。

更新日期：2017-11-20

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