Four new meroterpenoids identified as (R)-4-((2,2-dimethylchroman-6-yl)methyl)-3-(4-hydroxyphenyl)-5-methoxyfuran-2(5H)-one (1), 1-(2,2-dimethylchroman-6-yl)-3-(4-hydroxyphenyl)propan-2-one (2), (R,E)-3-(2,2-dimethylchroman-6-yl)-4-hydroxy-5-((2-(2-hydroxypropan-2-yl)-2,3-dihydrobenzofuran-5-yl)methylene)furan-2(5H)-one (3), methyl (R)-2-(2-(2-hydroxypropan-2-yl)-2,3-dihydrobenzofuran-5-yl) acetate (4), along with nine known compounds (5–13) were isolated from a chemical-epigenetic culture of Aspergillus terreus OUCMDZ-2739 with 10 μM trichostatin A (TSA). Under the same condition without TSA, A. terreus OUCMDZ-2739 produced different compounds (14–20), supporting that the chemical-epigenetic modification of fungi could enrich the chemodiversity of the fungal products. The cytotoxicity was observed for compound 8 against K562 cell, 9 against MCF-7 and K562 cells and 12 against MCF-7 cell with IC₅₀ values of 9.5, 10.1, 13.0 and 8.5 μM, respectively. Compounds 3, 8 and 17 exhibited stronger α-glucosidase inhibition than 1-deoxynojirimycin and acarbose (positive controls) with IC₅₀ values of 24.8, 1.2, 61.6, 191.7 and 555.1 μM, respectively. The enzyme kinetics study further indicated that compound 8 was an anticompetitive inhibitor with K_i value of 1.42 μM.

鉴定为（R）-4-（（2,2-二甲基苯并吡喃-6-基）甲基）-3-（4-羟基苯基）-5-甲氧基呋喃-2（5 H）-的一个新的四类萜类化合物（1），1 -（2,2-二甲基苯并吡喃-6-基）-3-（4-羟基苯基）丙-2-一（2），（R，E）-3-（2,2-二甲基苯并吡喃-6-基）-4 -羟基-5-（（2-（2-羟基丙-2-基）-2,3-二氢苯并呋喃-5-基）亚甲基）呋喃-2（5 H）-一（3），甲基（R）-2 - （2-（2-羟基丙-2-基）-2,3-二氢苯并呋喃-5-基）乙酸甲酯（4），具有九个已知化合物（沿5 - 13）从一个化学-后生培养物中分离土曲霉OUCMDZ-2739与10  μ中号曲古抑菌素A（TSA）。下而不TSA相同条件下，土曲霉OUCMDZ-2739产生的不同的化合物（14 - 20），支持该真菌的化学-表观遗传修饰可以丰富真菌产品的chemodiversity。观察到的细胞毒性对化合物8对K562细胞，9针对MCF-7细胞和K562细胞和12针对与IC MCF-7细胞_50倍的9.5的值，10.1，13.0和8.5  μ分别男，。化合物3，8和17显示出更强的α葡萄糖苷酶抑制比IC 1-脱氧野尻霉素和阿卡波糖（阳性对照）₅₀ 24.8，1.2，61.6，191.7和555.1的值 μ分别男，。酶动力学研究进一步表明，化合物8是一个反竞争抑制剂ķ_我的1.42值 μ M.