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Copper-catalyzed remote CH ethoxycarbonyldifluoromethylation of 8-aminoquinolines with bis(pinacolato)diboron as reductant
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-11-20 , DOI: 10.1016/j.tetlet.2017.11.037
Shuaijun Han , Apeng Liang , Xiaoxiao Ren , Xianying Gao , Jingya Li , Dapeng Zou , Yangjie Wu , Yusheng Wu

A simple protocol for the copper/B2pin2-catalyzed CH ethoxycarbonyldifluoromethylation of 8-aminoquinoline scaffolds with functionalized difluoromethyl bromides and iodines was developed, affording the desired products in moderate to good yields. This reaction was carried out under mild conditions and features good substrate tolerance.



中文翻译:

以双(频哪醇)二硼为还原剂的8-氨基喹啉的铜催化远程C H乙氧基羰基二氟甲基化

开发了一种简单的方案,用于铜/ B 2 pin 2催化的8-氨基喹啉支架的C H乙氧基羰基二氟甲基化与功能化的二氟甲基溴化物和碘的混合物,以中等至良好的收率提供了所需的产物。该反应在温和的条件下进行,具有良好的底物耐受性。

更新日期:2017-11-20
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