A new synthetic protocol for the one-pot synthesis of 2-(4-hydroxybutyl)-3-(3-hydroxypropyl)quinolines and 3-(2-hydroxyethyl)-2-(3-hydroxypropyl)-quinolines based in the AB² imino-Diels-Alder reaction is reported. The protocol describes simple and efficient preparation of 2,3-disubstituted quinolines using a domino-sequential process and applying the chemical properties of cyclic enol ethers, such as 2,3-dihydrofuran and 3,4-dihydro-2H-pyran and diverse arylamines, through an imino-Diels-Alder process between an in situ generated 2-azadiene and another equivalent of the cyclic enol, catalyzed by BiCl₃, and followed by the aromatization (oxidation) process guided by the MnO₂.

基于AB ²的一锅式合成2-（4-羟丁基）-3-（3-羟丙基）喹啉和3-（2-羟乙基）-2-（3-羟丙基）喹啉的新合成方案据报道有亚氨基Diels-Alder反应。该协议描述了使用多米诺序列法简单有效地制备2,3-二取代喹啉并应用环状烯醇醚的化学性质，例如2,3-二氢呋喃和3,4-二氢-2 H-吡喃，并且种类繁多芳基胺，通过BiCl ₃催化的原位生成的2-氮杂二烯与另一当量的环状烯醇之间的亚氨基Diels-Alder工艺，然后在MnO _2的引导下进行芳构化（氧化）过程。