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A Tamao–Fleming oxidation route to dipeptides bearing N,O-acetal functionality
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-11-20 , DOI: 10.1016/j.tetlet.2017.11.036
Sherif M.S. Ibrahim , Koushik Banerjee , Kara A. Slater , Gregory K. Friestad

Tamao–Fleming oxidation of the N-dimethylphenylsilylmethyl group linked to the nitrogen of a peptide bond enables access to dipeptide N,O-acetal functionality. The N-silylmethyl functionality serves as a latent form of the N,O-acetal which is revealed after peptide bond construction.



中文翻译:

带有NO-缩醛官能度的二肽的Tamao-Fleming氧化途径

与肽键氮相连的N-二甲基苯基甲硅烷基甲基的Tamao-Fleming氧化使得能够使用二肽N,O-缩醛官能团。所述Ñ -silylmethyl功能作为一个潜在形式N,O,其肽键施工后显露-acetal。

更新日期:2017-11-20
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