Streptavidin as a Scaffold for Light-Induced Long-Lived Charge Separation,Chemistry - A European Journal

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Streptavidin as a Scaffold for Light-Induced Long-Lived Charge Separation
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2017-11-20 07:56:13 , DOI: 10.1002/chem.201703885
Sascha G. Keller ₁ , Andrea Pannwitz ₂ , Hendrik Mallin ₁ , Oliver S. Wenger ₂ , Thomas R. Ward ₁

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Charge separation on a protein surface: Long-lived photo-driven charge separation is achieved by assembling a triad consisting of a biotinylated triarylamine and a Ru^II–streptavidin conjugate bearing a methyl viologen electron-acceptor covalently linked to the N-terminus of streptavidin (Sav). The rate and the lifetime of the electron transfer was improved by introduction of a negative patch through mutagenesis close to the binding pocket of Sav.

中文翻译：

链霉亲和素作为光诱导的长寿命电荷分离的支架。

蛋白质表面上的电荷分离：通过组装由生物素化的三芳基胺和Ru ^II –链霉亲和素共轭物组成的三元组，该三联体具有与链霉亲和素的N端共价连接的甲基紫精电子受体，从而实现长寿命的光驱动电荷分离Sav）。通过在Sav的结合口袋附近诱变引入负片，可以改善电子转移的速率和寿命。

更新日期：2017-11-20

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