Novel cytochrome P450 (CYP6D1) and voltage sensitive sodium channel (Vssc) alleles of the house fly (Musca domestica) and their roles in pyrethroid resistance,Pest Management Science

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Novel cytochrome P450 (CYP6D1) and voltage sensitive sodium channel (Vssc) alleles of the house fly (Musca domestica) and their roles in pyrethroid resistance
Pest Management Science ( IF 3.8 ) Pub Date : 2018-01-05 , DOI: 10.1002/ps.4798
Jing Pan _{1,

2} , Chan Yang _{1,

2} , Yan Liu _{1,

2} , Qi Gao _{1,

2} , Mei Li ₁ , Xinghui Qiu ₁

Affiliation

The house fly Musca domestica is an important disease vector. Point mutation‐mediated target‐site insensitivity of the voltage sensitive sodium channel (VSSC) and increased detoxification mediated by cytochrome P450 (CYP6D1) overexpression have been characterized as two major mechanisms of pyrethroid resistance. In this study, genetic mutations in the Vssc and CYP6D1 genes and their contribution to pyrethroid resistance were investigated.

中文翻译：

家蝇（家蝇）的新型细胞色素P450（CYP6D1）和电压敏感钠通道（Vssc）等位基因及其在拟除虫菊酯抗药性中的作用

家蝇家蝇是一个重要的病媒。点突变介导的电压敏感钠通道（VSSC）的靶位不敏感性和由细胞色素P450（CYP6D1）过度表达介导的解毒作用增加是拟除虫菊酯抗药性的两个主要机制。在这项研究中，研究了Vssc和CYP6D1基因的遗传突变及其对拟除虫菊酯抗药性的影响。

更新日期：2018-01-05

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