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Promise of Salivary MicroRNA for Assessing Concussion
JAMA Pediatrics ( IF 24.7 ) Pub Date : 2018-01-01 , DOI: 10.1001/jamapediatrics.2017.3924
William P. Meehan 1 , Rebekah Mannix 2
Affiliation  

Despite the marked increase in clinical and basic scientific investigation into concussive brain injury in recent years,1 the diagnosis and assessment of a concussion remains largely based on the reporting of symptoms.2 The symptoms of a concussion are nonspecific and can be caused by many etiologies. The biological basis of concussion symptoms has not been well-characterized and concussion symptoms do not always correlate with more objective measures of injury, such as neurocognitive testing. It therefore remains unclear whether persistent symptoms represent the continuation of concussion pathophysiology, are due to other contributing etiologies, or are the result of concussion management strategies that involve restricting activity.3 However, most children demonstrate persistent symptoms of a concussion 1 month after their injury.4,5 Given this large disease burden, objective measures of injury would be highly useful for making the diagnosis of a concussion, monitoring recovery, and identifying those at risk for prolonged symptoms after an injury.



中文翻译:

唾液MicroRNA评估脑震荡的承诺。

尽管近年来脑震荡的临床和基础科学研究显着增加,1脑震荡的诊断和评估仍主要基于症状的报告。2脑震荡的症状是非特异性的,可能是由多种病因引起的。脑震荡症状的生物学基础尚未被很好地表征,脑震荡症状并不总是与更客观的损伤度量相关,例如神经认知测试。因此,尚不清楚持续的症状是否代表脑震荡病理生理学的继续,是由于其他病因,还是由涉及限制活动的脑震荡管理策略的结果。3但是,大多数儿童受伤后1个月表现出持续性脑震荡症状。4 ,5鉴于这种大疾病负担,伤害的客观措施将是使脑震荡的诊断,恢复监测,并确定那些在危险中为受伤后长时间的症状是非常有用的。

更新日期:2018-01-02
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