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First synthetic approach towards K-259-2, a unique calmodulin antagonist
Tetrahedron ( IF 2.1 ) Pub Date : 2017-11-16 , DOI: 10.1016/j.tet.2017.11.037 Shyam Basak , Smita Mandal , Dipakranjan Mal
中文翻译:
独特的钙调蛋白拮抗剂K-259-2的第一种合成方法
更新日期:2017-11-16
Tetrahedron ( IF 2.1 ) Pub Date : 2017-11-16 , DOI: 10.1016/j.tet.2017.11.037 Shyam Basak , Smita Mandal , Dipakranjan Mal
K-259-2, a unique calmodulin antagonist, is an allyl chain containing anthraquinone natural product. A regiospecific synthetic approach towards K-259-2 is herein represented. The study also showcases a protocol for synthesizing heavily substituted bromo naphthoate which was found to be suitable for fabricating the K-259-2 motif.
中文翻译:
独特的钙调蛋白拮抗剂K-259-2的第一种合成方法
K-259-2是独特的钙调蛋白拮抗剂,是一条含有蒽醌天然产物的烯丙基链。本文描述了针对K-259-2的区域特异性合成方法。该研究还展示了用于合成重取代的萘甲酸溴酯的方案,该方案被发现适合于制造K-259-2基序。