Copper/Iron‐Cocatalyzed Cascade Perfluoroalkylation/Cyclization of 1,6‐Enynes with Iodoperfluoroalkanes,Advanced Synthesis & Catalysis

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Copper/Iron‐Cocatalyzed Cascade Perfluoroalkylation/Cyclization of 1,6‐Enynes with Iodoperfluoroalkanes
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-12-11 , DOI: 10.1002/adsc.201701258
Xiao-Feng Xia ₁ , Jipan Yu ₂ , Dawei Wang ₁

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A copper/iron‐cocatalyzed fluoroalkylative cyclization of 1,6‐enynes with readily available iodoperfluoroalkanes reagents for the synthesis of the corresponding fluoroalkylated pyrrolidines and benzofuran derivatives is reported. This novel protocol provides a mild method for the construction of Csp³‐CF₂ and exocyclic double bonds in one step with high regio‐ and stereo‐selectivities.

中文翻译：

铜/铁共催化级联全氟烷基化/碘代氟代烷烃对1,6-烯炔的环化反应

据报道，铜/铁共催化的1,6-炔烃的氟代烷基化与易得的碘代氟代烷烃试剂合成了相应的氟代烷基化的吡咯烷和苯并呋喃衍生物。这种新颖的协议提供了一种温和的方法，可一步构建具有高区域选择性和立体选择性的C sp ³ -CF ₂和环外双键。

更新日期：2017-12-11

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