Like cervical cancer, anal cancer and its direct precursor lesion, high-grade anal intraepithelial neoplasia (AIN), are caused by persistent infections with human papillomaviruses (HPV).¹ The natural history of HPV in cervical cancer has been comprehensively investigated. In the more than 40 HPV types infecting the anogenital tract, high-risk HPV-types and possible or probable high-risk types for the development of cervical cancer have been defined.² Cervical cancer is preventable by regular screening.

中文翻译：

---

HPV16在预防肛门癌中的重要性

像宫颈癌一样，肛门癌及其直接的前体病变（高级别的肛门上皮内瘤变（AIN））是由人类乳头瘤病毒（HPV）持续感染引起的。¹已对宫颈癌中HPV的自然病史进行了全面研究。在感染生殖道的40多种HPV类型中，已经定义了高危型HPV型以及可能或可能发生的高危型宫颈癌。²定期检查可以预防宫颈癌。