Three-Dimensional Barcodes with Ultrahigh Encoding Capacities: A Flexible, Accurate, and Reproducible Encoding Strategy for Suspension Arrays,Chemistry of Materials

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Three-Dimensional Barcodes with Ultrahigh Encoding Capacities: A Flexible, Accurate, and Reproducible Encoding Strategy for Suspension Arrays
Chemistry of Materials ( IF 7.2 ) Pub Date : 2017-11-17 00:00:00 , DOI: 10.1021/acs.chemmater.7b03811
Si Lu ₁ , Ding Shengzi Zhang ₁ , Dan Wei ₁ , Ye Lin ₁ , Shunjia Zhang ₁ , Hao He ₁ , Xunbin Wei ₁ , Hongchen Gu ₁ , Hong Xu ₁

Affiliation

Novel 3D barcodes with an extraordinarily high encoding capacity are developed through a flexible, accurate, and reproducible method. Here, the three dimensions refer to the size, fluorescence emission wavelength, and intensity of the barcodes. As a proof of concept, a 3D barcode library with an encoding capacity of 100 flow cytometry-distinguishable barcodes is achieved successfully by combining the multiscaled host particles with a set of guest nanoparticles owning to their individual different fluorescent intensity via an ingenious host–guest structure, where fluorescein isothiocyanate and a kind of quantum dots are separately loaded inside. Five-plexed tumor marker detection is further implemented, and the results demonstrate the strong feasibility of 3D barcodes in multiplex assays.

中文翻译：

具有超高编码能力的三维条形码：悬挂阵列的灵活，准确且可重现的编码策略

通过灵活，准确和可重现的方法，开发出具有超高编码能力的新型3D条形码。在此，这三个维度是指条形码的大小，荧光发射波长和强度。作为概念证明，通过将多尺度宿主颗粒与一组客体纳米颗粒（通过独特的宿主-客体结构拥有各自不同的荧光强度）结合起来，可以成功实现编码能力为100个流式细胞仪可区分的条形码的3D条码库，其中异硫氰酸荧光素和一种量子点分别装入内部。进一步实施了五重肿瘤标记物检测，结果证明了3D条码在多重分析中的强大可行性。

更新日期：2017-11-19

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