We report a tandem asymmetric aldehyde–alkyne–amine (A³) coupling-carboxylative cyclization sequence for the highly enantioselective synthesis of chiral N-aryl 2-oxazolidinones. This is a rare example of a multicatalyst-promoted asymmetric tandem reaction using CO₂ as a C1 synthon. Notably, the copper species and ligand from the upstream A³ reaction are internally reused to facilitate the downstream silver-catalyzed carboxylative cyclization.

中文翻译：

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利用CO ₂作为串联的不对称A ³偶联-羧化环化序列为2-恶唑烷酮的C1结构单元。

我们报告了手性N-芳基2-恶唑烷酮的高度对映选择性合成的串联不对称醛-炔-胺（A ³）偶联-羧基化环化序列。这是使用CO ₂作为C1合成子的多催化剂促进的不对称串联反应的罕见例子。值得注意地，来自上游A ³反应的铜物质和配体在内部被再利用以促进下游银催化的羧基环化。