Nigegladines A–C (1–3), three thymoquinone dimers, were isolated from the seeds of Nigella glandulifera. Racemic 1 possesses a unique tricyclo[5.4.0.1^2,6]dodecane carbon skeleton, and compounds 2 and 3 are two unusual diterpenoid alkaloids with indole cores. Their structures were determined by extensive spectroscopic analyses, and that of 1 was confirmed by single-crystal X-ray diffraction. Both (+)-1 and (−)-1 exhibited significant protective effects against hypoxia/reoxygenation-induced H9c2 myocardial cell injury.

中文翻译：

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Nigegladines A-C，三麝香醌二聚体从黑种草短柄

Nigegladines A-C（1 - 3），三成百里醌二聚物，从种子中分离黑种草短柄。外消旋体1具有独特的三环[5.4.0.1 ^2,6 ]十二烷碳骨架，化合物2和3是两种具有吲哚核的不寻常的二萜生物碱。通过广泛的光谱分析确定它们的结构，并通过单晶X射线衍射确认其结构为1。（+）- 1和（-）- 1均表现出对缺氧/复氧诱导的H9c2心肌细胞损伤的显着保护作用。