Iron-Catalyzed Indolizine Synthesis from Pyridines, Diazo Compounds, and Alkynes,Organic Letters

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Iron-Catalyzed Indolizine Synthesis from Pyridines, Diazo Compounds, and Alkynes
Organic Letters ( IF 4.9 ) Pub Date : 2017-11-16 00:00:00 , DOI: 10.1021/acs.orglett.7b03252
Tim Douglas ₁ , Anca Pordea ₁ , James Dowden ₁

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The iron(III)-catalyzed synthesis of indolizines from commercially available alkyne, pyridine, and diazo precursors is reported. This mild, expedient method is tolerant of various solvents and proceeds with as little as 0.25 mol % [Fe(TPP)Cl]. Significantly, this multicomponent reaction is compatible with electrophilic alkynes; control experiments demonstrate the importance of the catalyst in promoting pyridinium ylide formation over background reactivity.

中文翻译：

由吡啶，重氮化合物和炔烃进行铁催化的吲哚嗪合成

据报道，铁（III）由市售的炔烃，吡啶和重氮前体合成了吲哚嗪。这种温和，简便的方法可耐受各种溶剂，并且只需低至0.25 mol％的[Fe（TPP）Cl]即可进行。值得注意的是，这种多组分反应与亲电炔烃相容。对照实验证明了催化剂在促进吡啶鎓叶立德形成中的重要性超过背景反应性。

更新日期：2017-11-16

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