Current understanding of how platelets localize coagulation to wound sites has come mainly from studies of a subpopulation of activated platelets. In this review, we summarize data from the last 4 decades that have described these platelets with a range of descriptive titles and attributes. We identify striking overlaps in the reported characteristics of these platelets, which imply a single subpopulation of versatile platelets and thus suggest that their commonality requires unification of their description. We therefore propose the term procoagulant platelet as the unifying terminology. We discuss the agonist requirements and molecular drivers for the dramatic morphological transformation platelets undergo when becoming procoagulant. Finally, we provide perspectives on the biomarker potential of procoagulant platelets for thrombotic events as well as on the possible clinical benefits of inhibitors of carbonic anhydrase enzymes and the water channel Aquaporin-1 for targeting this subpopulation of platelets as antiprocoagulant antithrombotics.

当前对血小板如何将凝血定位于伤口部位的当前理解主要来自对活化血小板亚群的研究。在这篇综述中，我们总结了过去40年的数据，这些数据用一系列描述性的标题和属性描述了这些血小板。我们在这些血小板的报道特征中发现了明显的重叠，这暗示了通用血小板的单个亚群，因此表明它们的共性需要对其描述进行统一。因此，我们提出术语促凝血小板作为统一术语。我们讨论了促凝剂对血小板发生剧烈形态转化的激动剂要求和分子驱动因素。最后，