PLOS Biology ( IF 7.8 ) Pub Date : 2017-11-16 , DOI: 10.1371/journal.pbio.2003850 Kevin M Esvelt 1 , Neil J Gemmell 2
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Interest in developing gene drive systems to control invasive species is growing, with New Zealand reportedly considering the nascent technology as a way to locally eliminate the mammalian pests that threaten its unique flora and fauna. If gene drives successfully eradicated these invasive populations, many would rejoice, but what are the possible consequences? Here, we explore the risk of accidental spread posed by self-propagating gene drive technologies, highlight new gene drive designs that might achieve better outcomes, and explain why we need open and international discussions concerning a technology that could have global ramifications.
中文翻译：
保护需要安全的基因驱动
人们对开发基因驱动系统来控制入侵物种的兴趣日益浓厚，据报道，新西兰正在考虑将这项新兴技术作为在当地消除威胁其独特动植物群的哺乳动物害虫的一种方法。如果基因驱动成功消灭这些入侵种群，许多人会感到高兴，但可能的后果是什么？在这里，我们探讨了自我繁殖的基因驱动技术造成的意外传播的风险，强调了可能取得更好结果的新基因驱动设计，并解释了为什么我们需要就可能产生全球影响的技术进行公开的国际讨论。
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