Transition-Metal-Free Intermolecular α-Arylation of Ketones via Enolonium Species,Organic Letters

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Transition-Metal-Free Intermolecular α-Arylation of Ketones via Enolonium Species
Organic Letters ( IF 4.9 ) Pub Date : 2017-11-15 00:00:00 , DOI: 10.1021/acs.orglett.7b03064
Shimon Maksymenko ₁ , Keshaba N. Parida ₁ , Gulab K. Pathe ₁ , Atul A. More ₁ , Yuriy B. Lipisa ₁ , Alex M. Szpilman ₁

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Herein it is shown, for the first time, that enolonium species are powerful electrophiles capable of reacting with aromatic compounds in an intermolecular manner to afford α-arylated ketones. The reaction is compatible with a variety of functional groups, is of wide scope with respect to aromatic compounds and ketone, and even works for polymerization-prone substrates such as substituted pyrroles, thiophenes, and furans. Only 1.6 to 5 equiv of the commodity aromatic substrates is needed.

中文翻译：

通过En物种对酮的无过渡金属的分子间α-芳基化作用

在此首次表明，en烯是能够以分子间方式与芳族化合物反应以提供α-芳基化酮的强亲电试剂。该反应与多种官能团相容，对于芳族化合物和酮而言具有广泛的范围，甚至适用于易于聚合的底物，例如取代的吡咯，噻吩和呋喃。仅需要1.6至5当量的商品芳族底物。

更新日期：2017-11-15

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