An efficient procedure for the copper-catalyzed cross-coupling between a broad range of cyanamides and iodoalkenes is reported. Upon reaction with catalytic amounts of copper(I) iodide and 2,2′-bisimidazole in the presence of cesium carbonate in DMF at 80 °C, a fast, regioselective, and stereoretentive cross-coupling occurs. This reaction, which was found to have a broad substrate scope, provides the first general entry to N-alkenylcyanamides, building blocks that hold great synthetic potential.

中文翻译：

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铜催化氰胺的链烯基化

据报道，铜催化的广泛氰胺和碘代烯烃之间的交叉偶联的有效方法。在80℃下于碳酸铯中在碳酸铯存在下与催化量的碘化亚铜（I）和2,2'-双咪唑反应后，会发生快速，区域选择性和立体保持性交叉偶联。发现该反应具有广泛的底物范围，提供了N-链烯基氰酰胺的第一个一般入口，N-链烯基氰酰胺具有巨大的合成潜力。